JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salvador, R. A.
Right arrow Articles by Smith, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salvador, R. A.
Right arrow Articles by Smith, P. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 121, Issue 2, 258-265, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF CYSTEAMINE

Richard A. Salvador 1, Clarke Davison 1, and Paul K. Smith 1

1 Department of Pharmacology, The George Washington University School of Medicine, Washington 5, D. C.

Inorganic sulfate, taurine, cysteamine and cystamine were demonstrated in the urine of normal and x-irradiated male mice receiving S35-cysteamine. These findings corroborate reports of its degradation in rats. There appears to be no difference in the metabolism of this agent as a result of its presence during x-irradiation. Excretion of radioactivity, however, was significantly slower in the x-irradiated animal.

In man, as in the mouse, sulfate and taurine constituted the largest portion of the urinary excretory products. Several metabolites present in human urine were not seen in mouse urine. In man, the urinary end products differed under hypoxic conditions.

Submitted on June 7, 1957






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.