JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levine, R. M.
Right arrow Articles by Clark, B. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levine, R. M.
Right arrow Articles by Clark, B. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 121, Issue 1, 63-70, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

THE PHYSIOLOGICAL DISPOSITION OF OXYPHENONIUM BROMIDE (ANTRENYL) AND RELATED COMPOUNDS

Ruth Mitchell Levine 1 and Byron B. Clark 1

1 Department of Pharmacology, Tufts University School of Medicine, Boston, Massachusetts

Oxyphenonium is slowly metabolized by liver slices of the rat, mouse and dog and is slowly metabolized in the intact mouse. The intestinal absorption of oxyphenonium begins rapidly but reaches a maximum between 1 and 2 hours (18 per cent of the total dose) and does not continue to be appreciably absorbed beyond this time. The tissue distribution of oxyphenonium is primarily limited to the kidney, liver and small intestine, reaching the latter via biliary excretion. After oral administration less than 1 per cent of the dose is recovered in the urine while after intravenous administration 32 per cent is recoverable. Oxyphenonium is excreted in the urine by a combination of glomerular filtration and tubular secretion.

Results of studies of intestinal absorption, biliary excretion and complex formation of a number of analogues of oxyphenonium are also included.

Submitted on April 6, 1957






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.