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Journal of Pharmacology And Experimental Therapeutics, Vol. 121, Issue 1, 55-62, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

SECRETION OF DDT METABOLITES IN THE BILE OF RATS

Edward C. Burns 1, Paul A. Dahm 1, and Donald A. Lindquist 1

1 Department of Zoology and Entomology, Iowa State College, Ames

The bile is an important pathway for the elimination of the metabolites of DDT in the rat. As much as 20 per cent of subacute, oral doses of DDT in corn oil have been recovered by cannulation of the common bile duct a few hours after administration of the insecticide. The principal metabolite of DDT in the bile is an acidic compound believed to be DDA or a mixture of similar compounds.

Most of the DDT metabolites are voided in the feces; very little are eliminated via the urine.

When the common bile duct is ligated and excised, the kidneys play a major role in the elimination of DDT and its metabolites.

Submitted on April 6, 1957






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