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Journal of Pharmacology And Experimental Therapeutics, Vol. 121, Issue 1, 130-135, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

INTERACTION OF SEROTONIN AND LYSERGIC ACID DIETHYLAMIDE IN THE SIAMESE FIGHTING FISH

David L. Trout 1

1 Department of Physiology and Pharmacology, Duke University, Durham, North Carolina

Siamese fighting fish (Betta splendens) were subjected to a controlled stress situation involving hypoxia. LSD depressed the intensity of activity under these conditions, whereas serotonin increased it. LSD and serotonin, however, had the same effect in reducing the duration of almost continuous activity. When the two drugs were added together, serotonin potentiated the effect of LSD on intensity and increased its effect on duration.

Evidence is also presented suggesting that LSD produced perceptual or mood changes in Betta.

Submitted on May 6, 1957






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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.