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Journal of Pharmacology And Experimental Therapeutics, Vol. 120, Issue 4, 469-474, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

TOLERANCE TO SOME EFFECTS OF BARBITURATES

Richard E. Belleville 1 and H. F. Fraser 1

1 U. S. Department of Health, Education, and Welfare, Public Health Service, National Institute of Mental Health, Addiction Research Center, Lexington, Kentucky

Eighteen healthy male postaddicts who volunteered to take barbiturates for 90 days were studied by means of clinical observation and performance on psychomotor tests under control and chronic drug administration conditions, and following withdrawal of drugs. Ten men received 0.4 gram of secobarbital daily divided among four equal doses, and 8 men received pentobarbital in the same dose schedule.

The effects of both drugs were found to be quite similar. No appreciable effects on temperature, blood pressure, pulse, respiratory rate, caloric intake or body weight were observed during the course of the experiment. Tolerance was demonstrated on all measures showing an initial barbiturate effect, including hours of sleep, intoxication scores and psychomotor test performance.

Submitted on March 20, 1957






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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.