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Journal of Pharmacology And Experimental Therapeutics, Vol. 120, Issue 3, 375-378, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF SOME PHENOTHIAZINE DERIVATIVES IN INHIBITING APOMORPHINE-INDUCED EMESIS

Herbert Rosenkilde 1 and William M. Govier 1

1 Department of Pharmacology, Research Division, Schering Corporation, Bloomfield, New Jersey

Four phenothiazine derivatives were compared with chlorpromazine for their inhibitory potencies in apomorphine-induced emesis in dogs. On intravenous injection, Sch 3940 was about twenty-four times, and proclorperazine three times more active than chlorpromazine. With the small doses used, no side effects could be observed. Two other compounds, mepazine and promazine, showed little or no activity in the doses used.

Submitted on February 26, 1957






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