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Journal of Pharmacology And Experimental Therapeutics, Vol. 120, Issue 3, 349-353, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

PREVENTION OF EXPERIMENTAL POLYARTHRITIS WITH SODIUM AUROTHIOMALATE

Gaëtan Jasmin 1

1 Institut de Médicine et de Chirurgie expérimentales, Université de Montréal, Montréal, Canada

An experimental polyarthritis develops in rats following the intraperitoneal injection of 1 ml. of Murphy Rat Lymphosarcoma exudate. It was observed that gold therapy (Myochrysine) is equally effective in intact or adrenalectomized animals when the latter are maintained either on DOC-Ac or COL-Ac.

Nephroealcinosis resulting from massive treatment with myochrysine was evident on1y in adrenalectomized rats receeiving DOC-Ac. It is suggested that combined treatment of gold and COL-Ac might be beneficial as they both possess anti-inflammatory properties and the nephrotoxic action of gold is prevented by COL-Ac.

Submitted on February 11, 1957






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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.