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Journal of Pharmacology And Experimental Therapeutics, Vol. 120, Issue 3, 334-339, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

RELEASE OF SEROTONIN FROM BLOOD PLATELETS BY RESERPINE IN VITRO

Arvid Carlsson 1, Parkhurst A. Shore 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland

Reserpine incubated at 37° C with platelet-enriched plasma induces the release of serotonin from platelets. The alkaloid does not simply displace serotonin from its binding sites for one molecule of reserpine releases hundreds of serotonin molecules. The ability of reserpine to release serotonin is temperature dependent being appreciably lower at room temperature and almost negligible at 2° C.

Only those Rauwolfia alkaloids with reserpine-like pharmacologic properties cause the release of serotonin from platelets. In contrast, chlorpromazine, lysergic acid diethylamide, phenobarbital and 48/80 do not release serotonin.

Submitted on February 11, 1957




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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.