JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Katzung, B.
Right arrow Articles by Scheider, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Katzung, B.
Right arrow Articles by Scheider, F.
Journal of Pharmacology And Experimental Therapeutics, Vol. 120, Issue 3, 324-333, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

FREQUENCY-FORCE RELATIONSHIP IN THE RABBIT AURICLE AND ITS MODIFICATION BY SOME METABOLIC INHIBITORS

B. Katzung 1, H. Rosin 1, and F. Scheider 1

1 Department of Pharmacology, State University of New York, Upstate Medical Center, Syracuse

The effect of frequency of contraction on isometric contractility of rabbit auricular muscle has been studied over a wide range of frequencies. This frequency force relationship can be presented as a triphasic curve which has been termed the "S-shaped curve".

The action of a number of metabolic inhibitors on the isolated auricle can be modified both qualitatively and quantitatively by rate variations.

It is postulated that in cardiac muscle at least two processes influence contractility: a) energy production and b) the potentiating phenomenon elicited by high rate of stimulation. The complex actions of some inhibitors on cardiac contractility can be partially explained by differential action on these two processes.

Submitted on February 8, 1957






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.