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Journal of Pharmacology And Experimental Therapeutics, Vol. 119, Issue 3, 390-394, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

AGENTS AFFECTING APOMORPHINE-INDUCED VOMITING

Eldon M. Boyd 1 and Wilfred A. Cassell 1

1 Department of Pharmacology, Queen's University, Kingston, Ontario, Canada

An apomorphine-induced vomiting syndrome in dogs was found to be inhibited by stemetil, meclizine, reserpine, amphetamine, possibly systral and exposure to excitant doses of 110 volt electric current. It was not affected by Kolton, Pacatal, homatropine methylbromide, propantheline, cycrimine, methscopolamine, dicyclomine, Schering 1667, pipradrol, hyoscine or atropine. The emetic syndrome was augmented by epinephrine and methantheline.

Submitted on September 13, 1956






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