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Journal of Pharmacology And Experimental Therapeutics, Vol. 119, Issue 3, 299-309, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

CENTRAL ACTIVITY AND STRUCTURE IN A SERIES OF WATER-SOLUBLE STEROIDS

S. K. Figdor 1, M. J. Kodet 1, B. M. Bloom 1, E. J. Agnello 1, S. Y. P'An 1, and G. D. Laubach 2

1 Research Division, Chas. Pfizer and Co., Inc., Brooklyn, New York
2 Research Divisiob, Chas. Pfizer and Co., Inc., Brooklyn, New York

A general survey of the central effects of a series of intravenously administered C-21 steroids has been carried out in the mouse. A high degree of depressant activity was found to be characteristic of nuclear-saturated 3,20 and 3,20,21 oxygenated steroids and their water-soluble esters.

Additional nuclear substitution typically reduced or abolished the depressant activity, usually with substitution of central stimulant effects.

Submitted on August 23, 1956




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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.