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Journal of Pharmacology And Experimental Therapeutics, Vol. 119, Issue 2, 294-298, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

BIOASSAY OF POTENTIAL ATARAXIC AGENTS AGAINST AUDIOGENIC SEIZURES IN MICE

N. P. Plotnikoff 1 and D. M. Green 1

1 Research Division , Nepera Chemical Company, Yonkers, New York

A technique has been devised to screen potential ataraxic agents by their ability to protect against audiogenic seizures in mice. Comparative standards were established by use of chlorpromazine, reserpine and meprobamate.

NC 1318, 1428, 1457, 1540 and 1541, a group of new hemiacetals, all proved effective antagonists of audiogenic seizures in mice. Of these, the most potent was NC 1457; chemically, (2,2,2-trichloro-1-[1-ethyl-1-methyl-(2-propyne-1-oxy)] ethanol).

Submitted on August 19, 1956




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S. Beck and D. Gavin
Suceptibility of mice to audiogenic seizures is increased by handling their dams during gestation
Science, July 30, 1976; 193(4251): 427 - 428.
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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.