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Journal of Pharmacology And Experimental Therapeutics, Vol. 119, Issue 2, 240-247, 1957
Copyright © 1957 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF d-LYSERGIC ACID DIETHYLAMIDE AND ITS BROM DERIVATIVE ON CARDIOVASCULAR RESPONSES TO SEROTONIN AND ON ARTERIAL PRESSURE

G. C. Salmoiraghi 1, J. W. McCubbin 1, and Irvine H. Page 1

1 The Research Division of the Cleveland Clinic Foundation, and the Frank E. Bunts Educational Institute , Cleveland, Ohio

d-Lysergic acid diethylamide (LSD) and its brom derivative (BOL), in larger dosage, effectively antagonized pressor-depressor responses to serotonin in rats. In cats, they showed slight and irregular activity against systemic responses to serotonin and, in dogs, BOL exhibited weak and inconstant activity. The vasoconstrictor responses to serotonin in a perfused extremity were also poorly antagonized by BOL; antagonistic activity, when present, was nonspecific. BOL, like ergotamine, failed also to prevent the chemoceptor stimulant action of serotonin in dogs.

BOL caused sharp and partly sustained fall in arterial pressure when given by quick injection to anesthetized rats. This effect was less marked in cats and dogs. LSD caused rises in pressure in rats and small falls in pressure in cats. Inactivation of the sympathetic nervous system enhanced the pressor response to LSD and diminished the depressor effect of BOL in rats and diminished the depressor effect of BOL and LSD in cats.

LSD or BOL given chronically by mouth had no effect on arterial pressures of chronic renal or neurogenic hypertensive dogs.

Submitted on September 13, 1956




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Copyright © 1957 by the American Society for Pharmacology and Experimental Therapeutics.