THE INFLUENCE OF SOME ALCOHOLS ON THE UPTAKE OF TETRAETHYLAMMONIUM ION BY RENAL SLICES OF THE DOG

¹ Department of Pharmacology, State University of New York, Upstate Medical Center, Syracuse, New York

Tetraethylammonium ion (TEA) transport in dog renal slices is increased by a series of alcohols. The relationship between carbon chain length of the alcohols and molar concentration necessary to produce a 40 per cent increase in TEA transport was determined. The longer the chain length the lower the concentration of alcohol needed to produce an increase in TEA uptake (figure 2).Thermodynamic activity of the alcohol concentrations thus determined was calculated from Ferguson's (1939) data and in our series "activity" was found to be relatively constant. The alcohol-induced stimulation of TEA uptake was not inhibited by fluoroacetate or malonate but could be inhibited by Antabuse. The alcohols do not significantly change the outflux of TEA from dog renal slices.