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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 4, 446-450, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

CONCENTRATION OF MORPHINE IN BLOOD AND BRAIN AFTER INTRAVENOUS INJECTION OF MORPHINE IN NON-TOLERANT, TOLERANT AND NEOSTIGMINE-TREATED RATS

John C. Szerb 1 and David H. McCurdy 1

1 Department of Pharmacology, Dalhousie University, Halifax, N. S., Canada

The elimination of free morphine from the blood of non-tolerant mats follows a first order reaction. In tolerant rats, free morphine is eliminated more rapidly from the blood and the rate does not follow a first order reaction. More bound morphine appears in the blood of tolerant than in non-tolerant rats 60 minutes after the injection.

There is less free morphine in the brains of tolerant rats than in non-tolerant animals, one and three hours after the injection of 75 mgm./kgm. of morphine. This difference however, does not explain tolerance.

Neostigmine, although potentiating the effect of morphine, does not increase the concentration of morphine in blood and brain tissue.

Submitted on July 2, 1956






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.