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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 2, 239-247, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

EXPERIMENTAL VENTRICULAR ARRHYTHMIAS FOLLOWING HARMAN METHOSULFATE

A. Scriabine 1 and D. E. Hutcheon 2

1 Research Laboratories, Chas. Pfizer & Co., Inc., Brooklyn, New York
2 Research Laboratires, Chas. Pfizer & Co., Inc., Brooklyn, New York

Harman methosulfate was demonstrated to produce ventricular fibrillation in combination with epinephrine in cats and dogs under pentobarbital anesthesia.

The incidence of ventricular fibrillation appeared to depend on the dose of harman methosulfate, the dose of epinephrine, and the time interval between harman and epinephrine injections.

Dibenamine (3 mgm./kgm.) reduced the incidence of ventricular fibrillation after harman methosulfate and epinephrine demonstrating a possible usefulness of these substances in the screening of antifibrillatory agents.

The ability of harman methosulfate to induce rhythmic contractions of isolated papillary muscles indicated that the mechanism of cardiac arrhythmias produced by harman methosulfate was based primarily on this direct action on the ventricular myocardium.

Submitted on June 16, 1956






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.