A STUDY OF THE CHEMICAL CONFIGURATION RESPONSIBLE FOR THE ANTIVERATRINIC ACTIVITY OF CINCHONA ALKALOIDS AND CUPREINES

¹ Department of Pharmacology and Experimental Therapeutics, Sawai Man Singh Medical College, Jaipur, India

The studies on the antivertrinic activity of cinchona alkaloids, eupreines and related compounds have revealed that changes in the steric configuration do not have any effect on the antiveratrinic property of these compounds in frog skeletal muscle. The presence of the quinoline ring appears to be responsible for the antiveratrinic activity and the quinuclidine ring may have no importance in the determination of this property. Both the secondary alcoholic group and the vinyl group also appear to be important for the antiveratrinic property. Alkoxyl substitutions at the 6'-carbon are significant and it has been observed that the activity increases with the increase in size the alkoxyl radical in the compounds reported here.