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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 2, 153-161, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGIC ACTIVITY OF agr-(4-PIPERIDYL)-BENZHYDROL HYDROCHLORIDE (AZACYCLONOL HYDROCHLORIDE); AN ATARACTIVE AGENT

Barbara B. Brown 1, Donald L. Braun 1, and Robert G. Feldman 1

1 Department of Pharmacology, Scientific Laboratories, The Wm. S. Merrell Co., Cincinnati 15, Ohio

The compound agr-(4-piperidyl)-benzhydrol hydrochloride, azacyclonol, causes depressed activity in mice and rats when small to moderate doses are administered but causes stimulation in large doses. Cats and dogs respond to azacyclonol only by stimulation.

Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine, and it antagonizes morphineinduced stimulation in cats.

Hexobarbital hypnosis is prolonged by azacyclonol, and can be re-induced by azacyclonol after the mice are fully awake.

The intravenous injections of azacyclonol in subjects with well-developed LSD-induced psychoses frequently caused prompt relief of the mental symptomatology.

Submitted on May 12, 1956






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.