JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 2, 148-152, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGY OF THE RETICULO-ENDOTHELIAL SYSTEM. 1. BLOCKADE BY POLYVINYLPYRROLIDONE (PVP) AS MEASURED WITH RADIO-CHROMIC PHOSPHATE IN THE RABBIT

John H. Weikel Jr. 1 and Lehman M. Lusky 1

1 Division of Pharmacology, Food and Drug Administration, Department of Health, Education and Welfare, Washington 55, D. C.

The correlation between polyvinylpyrrolidone storage in the reticulo-endothelial system and functional activity of that system has been examined using radioactive chromic phosphate. Polyvinylpyrrolidone was shown to depress the rate of phagocytosis of the colloid. It also caused a change in the distribution of the chromic phosphate among the organs of the reticuloendothelial system with more taken up by the lungs and less by the spleens of those animals treated with polyvinylpyrrolidone.

Submitted on May 7, 1956






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