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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 1, 77-83, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

SOME PHARMACOLOGICAL EFFECTS OF N-PROPYL NITRATE

Edmund F. Murtha 1, Dorothy E. Stabile 1, and J. Henry Wills 1

1 Pharmacology Branch, Directorate of Medical Research, Chemical Warfare Laboratories, Army Chemical Center, Maryland

1. In the rabbit, n-propyl nitrate has an approximate intravenous LD50 of 225 mgm./kgm.; the compound is of comparatively low toxicity in the cat and dog also.

2. The results of this preliminary investigation suggest that the prompt hypotension which occurs during non-fatal n-propyl nitrate intoxication may be caused, in part, by a direct action of the compound on vascular smooth muscle. Cardiac effects may contribute to the hypotension; respiratory depression may also play a part in the lethal effects.

Submitted on May 9, 1956






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