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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 1, 39-45, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION OF DIGITALIS GLYCOSIDES AND THEIR METBOLITES WITHIN THE BODY OF THE RAT

B. T. Brown 1, E. E. Shepheard 1, and S. E. Wright 1

1 Pharmacology Department, University of Sydney, Sydney, Australia

Cardioactive metabolites as well as the free glycosides have been detected in the heart, liver, kidney, and circulating blood of the rat, immediately following the injection of digoxin and lanatoside C. The metabolites were the same as those found in urine. Digitoxin and its metabolite, previously found in rat urine, were detected in rat livers immediately after injection, but only the free glycoside could be detected in blood and kidney. Using chemical techniques only, no trace of digitoxin could be found in the heart.

The main portion of the dose of the glycosides is quickly removed from the blood, digitoxin most rapidly, followed by lanatoside C and digoxin. No trace of any cardioactive genin could be detected in any tissue after administration of these glycosides and when digitoxigenin was injected it produced a metabolite in the liver which differed from that formed from digitoxin.

Submitted on April 24, 1956






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