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Journal of Pharmacology And Experimental Therapeutics, Vol. 118, Issue 1, 123-128, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF AN ALDOXIME ON ACUTE SARIN POISONING

T. A. Loomis 1

1 Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

PAM (2-pyridine aldoxime methiodide) has no greatly significant therapeutic or prophylactic antidotal action in otherwise untreated acute lethal Sarin poisoning in mice.

PAM is capable of reactivating Sarin-inhibited serum cholinesterase in low concentrations but in high concentrations PAM inhibits serum cholinesterase.

The in vitro and in vivo reactivating effects of PAM on Sarin-inhibited serum cholinesterase can be produced with amounts of PAM which have little or no demonstrable direct inhibitory effect on serum cholinesterase.

In anesthetised dogs which are protected from the early acute lethal effects of Sarin by positive pressure artificial respiration, PAM will result in return of normal response to injected acetylcholine and a return of normal spontaneous effective respirations.

Submitted on May 28, 1956




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J. H. WILLS, A. M. KUNKEL, R. V. BROWN, and G. E. GROBLEWSKI
Pyridine-2-Aldoxime Methiodide and Poisoning by Anticholinesterases
Science, April 19, 1957; 125(3251): 743 - 744.
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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.