STUDIES ON THE RENAL TUBULAR TRANSPORT OF TETRAETHYLAMMONIUM ION IN RENAL SLICES OF THE DOG

¹ Department of Pharmacology and Physiology, State University of New York, Upstate Medical Center, Syracuse, N. Y.

The renal tubular transport mechanisms for PAH and TEA were compared and contrasted in renal slices of the dog. A number of factors such as time, pH of the buffer, ionic composition, substrates and inhibitors have been considered. The evidence indicates that these transport mechanisms are distinct and can be separated on the basis of their metabolic requirements. Thus the evidence indicates that the TEA transport mechanism can continue functioning after blocking the Krebs cycle by a number of inhibitors. It is thus likely that the TEA transport mechanism obtains its energy supply from a source other than the Krebs cycle.