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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 4, 434-442, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

HYPOSTHENURIA AND OTHER RENAL EFFECTS OF HEXAMETHONIUM IN THE HYDROPENIC ANESTHETIZED DOG

F. Del Greco 1, A. C. Corcoran 1, and Irvine H. Page 1

1 Division of Research, The Cleveland Clinic Foundation, and the Frank E. Bunts Educational Institute, Cleveland, Ohio

Effects of hexamethonium on renal functions were examined in eleven experiments in hydropenic, anesthetized dogs in osmotic diuresis.

In most experiments, the depressor effect of hexamethonium on arterial pressure was associated with decreases in calculated renal vascular resistance, and variable, small changes in plasma clearance of PAH.

Clearance of mannitol was also variably affected, with considerable decreases in 4 and no changes or slight decreases in seven.

Dilution of the urine (hyposthenuria) occurred in 10 of 11 experiments, in 7 of which it was associated with increases in rates of urine flow, and in 4 with increased outputs of sodium and chloride.

The effects of hexamethonium blockade on water and electrolyte outputs point to the existence of neural influences on renal tubular reabsorptive functions. These may act either at the cellular level or, as logical economy suggests, they may affect reabsorption by altering distribution of blood flow around renal tubules.

Submitted on April 9, 1956






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.