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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 4, 414-419, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

BIOTRANSFORMATION PRODUCTS OF MEPERIDINE EXCRETED IN THE URINE OF MAN

N. P. Plotnikoff 1, E. Leong Way 1, and H. W. Elliott 1

1 The Department of Pharmacology and Experimental Therapeutics, University of Calfornia Medical Center, San Francisco, and the Department of Pharmacology and Toxicology, The University of Texas School of Medicine, Galveston

Employing the Brodie methyl orange and the Craig countercurrent techniques it was shown that meperidine is hydrolyzed and excreted in the urine of man as meperidinic acid and its corresponding acid conjugate. In addition, meperidine is demethylated to normeperidine which is then hydrolyzed to normeperidinic acid and partially conjugated.

Submitted on March 27, 1956




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.