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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 3, 358-361, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

ANESTHESIA. L. THE EFFECT OF CERTAIN NARCOTICS ON OXIDATIVE PHOSPHORYLATION

Arthur Wolpert 1, Edward B. Truitt Jr. 1, Frederick K. Bell 1, and John C. Krantz Jr. 1

1 Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland

A study of the effect of various narcotic drugs and alcohols upon oxidative phosphorylation of rat brain mitochondria failed to reveal a uniform pattern of inhibition even in high concentrations. The specific inhibitory action of certain of the barbiturates on oxidative phosphorylation does not appear to be representative of the class of central nervous system depressants.

Submitted on April 2, 1956






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.