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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 3, 317-321, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON VERATRUM ALKALOIDS. XXIV. THE INHIBITION BY VERATRAMINE AND VERATROSINE OF THE CARDIOACCELERATOR EFFECT OF ELECTRICAL STIMULATION OF THE ACCELERATOR TOR NERVES

I. R. Innes 1, H. W. Kosterlitz 1, and O. Krayer 1

1 Department of Physiology, University of Aberdeen, Scotland, and Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Veratramine and veratrosine injected in spinal cats in doses of 0.1 to 0.3 mgm./kgm. lower the basal heart rate and diminish the increase in rate due to stimulation of the accelerator nerves. Although these two effects usually occur simultaneously, they are not necessarily interrelated.

The basal heart rate decreases more slowly after injections of veratrosine than after veratramine. Apart from this, the effects of the two drugs on the heart rate and the accelerator responses appear to be similar.

Chronic sympathetic denervation of the heart does not fundamentally alter the effect of veratramine on the basal heart rate and on the accelerator action of epinephrine.

Submitted on March 8, 1956






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.