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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 245-252, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

DRUG ALTERATION OF TRANSMEMBRANE POTENTIALS IN ATRIAL PACEMAKER CELLS

Theodore C. West 1, Gertrude Falk 1, and Peter Cervoni 1

1 Department of Pharmacology, School of Medicine, University of Washington , Seattle

The sinoatrial node of isolated atria from rabbits was explored with the ultramicroelectrode technique of intracellular recording.

Either acetylcholine or l-epinephrine was added at the site of electrode impalement in order to observe the changes in configuration of pacemaker potentials associated with changing heart rate.

The primary effect of acetylcholine during retardation of rate was to reduce the slope of the pacemaker cell prepotential and the magnitude of the action potential. Epinephrine acceleration was associated with an increased slope of prepotential. Action potential magnitude was not significantly changed.

In the presence of either drug, there was evidence of reversible migration of pacemaker activity.

Submitted on February 13, 1956




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.