JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, E. A.
Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 237-244, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF QUINIDINE, PROCAINE AMIDE AND PYRILAMINE ON THE MEMBRANE RESTING AND ACTION POTENTIAL OF GUINEA PIG VENTRICULAR MUSCLE FIBERS

E. A. Johnson 1

1 Department of Pharmacology, University of Sydney, Sydney, Australia

1. The effects of quinidine, procaine amide and pyrilamine on the membrane resting and action potentials of ventricular muscle fibers of the guinea pig heart have been examined.

2. The mean resting potential was 52.8 mV, and the action potential 67.2 mV. The mean maximum rate of rise of the leading phase of the action potential was 121 volts/sec. The action potential duration at a stimulation rate of 240/min. was 70-100 msec.

3. No constant qualitative difference in action was observed between the three drugs. Their consistent effect was to reduce the maximum rate of rise of the actious potential. An accompanying reduction in membrane resting potential and overshoot sometimes occurred.

4. Evidence found suggests that the maximum rate of rise of the MAP may change independent of the membrane resting potential.

Submitted on February 6, 1956




This article has been cited by other articles:


Home page
 J CARDIOVASC PHARMACOL THERHome page
N. lost, L. Virag, A. Varro, and J. Gy. Papp
Comparison of the Effect of Class IA Antiarrhythmic Drugs on Transmembrane Potassium Currents in Rabbit Ventricular Myocytes
Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2003; 8(1): 31 - 41.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
D. J. BAILEY Jr.
Cardiotoxic Effects of Quinidine and Their Treatment: Review and Case Reports
Arch Intern Med, January 1, 1960; 105(1): 13 - 22.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.