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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 232-236, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

RELEASE OF BLOOD PLATELET SEROTONIN BY RESERPINE AND LACK OF EFFECT ON BLEEDING TIME

P. A. Shore 1, Alfred Pletscher 1, E. G. Tomich 1, Ronald Kuntzman 1, and B. B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Md.

The administration of reserpine to rabbits, rats or guinea pigs causes the liberation of serotonin from blood platelets without causing their disruption. The loss of over 90 per cent of platelet serotonin has no significant effect on bleeding time. It is improbable, therefore, that serotonin participates in the mechanism of hemostasis.

Submitted on February 3, 1956




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.