JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mayer, S. W.
Right arrow Articles by Morton, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mayer, S. W.
Right arrow Articles by Morton, M. E.
Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 197-201, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE DIRECT ANTITHYROID ACTION OF RESERPINE, CHLORPROMAZINE AND OTHER DRUGS

S. W. Mayer 1, F. H. Kelly 1, and M. E. Morton 1

1 Radioisotope Service, Veterans Administration Hospital, Long Beach, California and School of Medicine, University of California, Los Angles, California

Several compounds of medical or physiological interest were screened for direct antithyroid activity, by employing the thyroid slice-I131 technique. The following were found to be relatively strongly antithyroid at the indicated concentration (in mgm. per ml. of incubation medium). Reserpine (0.083), chlorpromazine (0.36), tetraethylammonium chloride (6.7), Regitine (0.33), Thiopental sodium (0.26, 0.026), colchicine (0.33), phenylbutazone (0.33, 0.033), Geigy G-25671 (0.33), Actrope (6.7). The predominant feature of the direct antithyroid action of all these agents, except chlorpromazine, was inhibition of the organic binding of I131 by the thyroid.

Submitted on January 20, 1956




This article has been cited by other articles:


Home page
 Arch SurgHome page
N. W. THOMPSON and W. J. FRY
Thyroid Crisis
Arch Surg, September 1, 1964; 89(3): 512 - 516.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
S. H. INGBAR
Physiological Considerations in Treatment of Diffuse Toxic Goiter
Arch Intern Med, June 1, 1961; 107(6): 932 - 951.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.