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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 190-196, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

NALORPHINE, A POTENT ANALGESIC IN MAN

Arthur S. Keats 1 and Jane Telford 1

1 Department of Anesthesiology, Baylor University College of Medicine and Jefferson Davis Hospital, Houston, Texas

The analgesic potency of nalorphine has been determined in post-operative patients and compared to morphine. Nalorphine is at least as potent an analgesic as morphine and represents a long-sought potent non-addicting analgesic although retaining a high side action liability. To achieve the full analgesic effect of nalorphine, nalorphine and morphine cannot be given to the same patient.

Some limited data on side action liability were presented and their relationship to clinical utility of nalorphine as a routine narcotic was discussed.

Further data on the importance of excluding placebo reactors in therapeutic trials were presented.

Submitted on January 16, 1956




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S. Archer, N. F. Albertson, L. S. Harris, A. K. Pierson, J. G. Bird, A. S. Keats, J. Telford, and C. N. Papadopoulos
Narcotic Antagonists as Analgesics
Science, August 17, 1962; 137(3529): 541 - 543.
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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.