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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 166-168, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

BLOCKADE BY BROM-LYSERGIC-ACID-DIETHYLAMIDE (BOL, OF THE POTENTIATING ACTION OF SEROTONIN AND RESERPINE ON HEXOBARBITAL HYPNOSIS

G. C. Salmoiraghi 1, L. Sollero 1, and Irvine H. Page 1

1 Research Division, Cleveland Clinic Foundation, and the Frank E. Bunts Educational Institute, Cleveland, Ohio

1. 2-Brom-d-lysergic-acid-diethylamide (BOL) produces a decrease of spontaneous activity in normal mice and rats and does not prolong the hypnotic action of hexobarbital.

2. The hypnotic effect of hexobarbital is prolonged by serotonin and reserpine and this action is blocked by injection of BOL.

Submitted on January 10, 1956




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.