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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 142-147, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE NEUROPHARMACOLOGIC PROPERTIES OF CERTAIN CONVULSANTS, ANTICONVULSANTS AND RESERPINE

Graham Chen 1 and Barbara Bohner 1

1 Research Laboratories, Parke, Davis & Company, Detroit 32, Michigan

The convulsant properties of NH4Ac, strychnine, picrotoxin, Metrazol, Coramine, and caffeine have been investigated by timed intravenous infusion in mice. Data on seizure patterns and on antagonism with various anticonvulsant agents under the influence of reserpine are presented to show how the convulsant effects of these agents may be clearly distinguished from one another by the difference in clonic and tonic-extensor seizure responses.

In strychnine-, Metrazol- and caffeine-induced convulsive seizures, a comparative study was made of the anticonvulsant effects of Dilantin, phenobarbital, barbital, Milontin, PM 396, Phenurone, carbromal, Tolserol, and sodium bromide. The results are elucidated from the standpoint of a Dilantin-type, mephenesin-type or barbital-type anticonvulsant effect.

Reserpine was found to have a suppressive effect on strychnine-induced tonic-extensor seizures and on Metrazol-induced clonic seizures in mice. This depressant action of reserpine was more pronounced when investigated jointly with barbital.

Submitted on December 27, 1955






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.