JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, R. P.
Right arrow Articles by Riopelle, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, R. P.
Right arrow Articles by Riopelle, A. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 2, 136-141, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF RESERPINE ON CONDITIONED AVOIDANCE BEHAVIOR IN NORMAL AND BRAIN-OPERATED MONKEYS

Richard P. Smith 1, Althea I. Wagman 1, and Arthur J. Riopelle 1

1 Department of Psychology, Emory University, Georgia

Three groups of brain-operated rhesus monkeys, differing as to size and location of lesion, and a group of nonoperated control monkeys, were trained to jump over a barrier in a shuttle-box to avoid shock. After extensive training the animals were injected with 0.15, 0.25 and 0.37 mgm./kgm. of reserpine. At least four days intervened between successive injections. Performance was tested 1, 2, 4, 6, and 10 hours after injection.

Results gathered by the present techniques revealed clear cut time-response curves which differed from dose level to dose level and from group to group. Greatest decrement in performance was shown at 4 and 6 hours after injection, with complete recovery occurring after 10 hours. Nonoperated animals were affected more severely than were the operated animals. Animals with lesions in the temporal lobes showed greater sparing than animals with frontal lesions.

Submitted on December 8, 1955




This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
E. KOPMANN and F. W. HUGHES
Potentiating Effect of Alcohol on Tranquilizers and Other Central Depressants
Arch Gen Psychiatry, July 1, 1959; 1(1): 7 - 11.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.