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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 1, 97-100, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

RELATIVE EFFECTIVENESS OF CERTAIN INHIBITORY CHEMICALS ON THE THREE TYPES OF POLIOMYELITIS VIRUS

Ariel C. Hollinshead 1 and Paul K. Smith 1

1 Department of Pharmacology, The George Washington University School of Medicine, Washington 5, D.C.

Equally cytopathogenic strains of types 1, 2 and 3 poliomyelitis virus were tested to see whether drugs with high inhibitory ratios against type 2 were equally active against all three types of poliomyelitis virus.

Most of the compounds were equal in their effect against type 2 and 3 virus but some were less effective against an equal number of infective doses of type 1 virus.

The compounds with the greatest differences in effectiveness were quinones or compounds capable of yielding a quinone Structure.






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.