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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 1, 62-67, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

ANTIARRHYTHMICS. VI. AJMALINE AND SERPENTINE IN EXPERIMENTAL CARDIAC ARRHYTHMIAS

R. B. Arora 1 and B. R. Madan 1

1 Department of Pharmacology and Experimental Therapeutics, S. M. S. Medical College, Jaipur, India

Ajmaline and serpentine have been found to be more active than quinidine in the following tests: (1) refractory period of isolated rabbit atria, (2) auricular fibrillation evoked in dogs by (a) acetylcholine and (b) aconitine, (3) auricular flutter produced in dogs by the injury-stimulation procedure and (4) hydrocarbon -epinephrine- induced ventricular arrhythmias in anesthetized dogs.

When the effects of these drugs were compared on the electrocardiograms of cats, ajmaline and serpentine were found to cause greater prolongation of refractory period and conduction time than quinidine.

Submitted on December 6, 1955




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