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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 1, 112-116, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

NALORPHINE-INDUCED "ABSTINENCE SYNDROME" IN MORPHINE-TOLERANT ALBINO RATS

Sukru Kaymakcalan 1 and L. A. Woods 1

1 Department of Pharmacology, University of Michigan, Ann Arbor

Nalorphine hydrochloride administered subcutaneously in a dose of 10 mgm./ kgm. to rats tolerant to 100 mgm./kgm. of morphine sulfate, administered subcutaneously twice daily, induces an "abstinence syndrome". The signs of this "abstinence syndrome" in the rat are sedation, loss of both muscular rigidity and exophthalmos and a marked increase in intestinal activity as evidenced by increased defecation, soft stools, and occasional diarrhea. A low grade tolerance is developed by the rat to 100 mgm./kgm. of nalorphine hydrochloride, administered twice daily.

Submitted on January 3, 1956




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.