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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 1, 106-111, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

MECHANISM OF LONG DURATION OF ACTION OF DIBENZYLINE

Sohan L. Agarwal 1 and Stewart C. Harvey 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

After its local intraarterial administration in the hind limb, Dibenzyline can produce a local blockade without any evidence of a systemic blockade 24 hours after the administration of the drug.

Cross-circulation experiments reveal that the sojourn of an effective concentration of the drug in the donor's circulation is no longer than 71/2 hours. The blockade in the recipient cat was always incomplete. At 8 hours, no active blocking agent could be transferred from the donor to the recipient.

The duration of blockade after a single dose lasted for 3 to 4 days, the residual effects lasting for 7 days.

It is therefore concluded that the long duration of action of Dibenzyline is due to a firm chemical combination of the drug with a cellular receptor substance, and not due to its storage in body fat.

Submitted on December 30, 1955




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.