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Journal of Pharmacology And Experimental Therapeutics, Vol. 117, Issue 1, 101-105, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF THE MERCURIAL DIURETIC, MERSALYL, ON THE CONCENTRATION OF PROTEIN-BOUND SULFHYDRYL IN THE CYTOPLASM OF DOG KIDNEY CELLS

E. J. Cafruny 1 and A. Farah 1

1 Department of Pharmacology, State University of New York, Upstate Medical Center, Syracuse, N. Y.

Renal protein-bound sulfhydryl concentrations were studied by a quantitative histochemical method in dogs.

The mercurial diuretic, mersalyl, lowered the concentration of sulfhydryl in cells of the terminal portions of proximal tubules, ascending limbs of the loops of Henle, and collecting ducts. BAL effectively counteracted mercurial diuresis and simultaneously restored sulfhydryl concentrations to control levels. The monothiol, cysteine, did not reverse the mercurial-induced changes in water and electrolyte excretion or sulfhydryl. Non-diuretic doses of mersalyl had no apparent effect on renal sulfhydryl concentrations.




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R. M. Komorn and E. J. Cafruny
Ethacrynic Acid: Diuretic Property Coupled to Reaction with Sulfhydryl Groups of Renal Cells
Science, January 10, 1964; 143(3602): 133 - 134.
[Abstract] [PDF]

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 Arch Intern MedHome page
C. T. RAY
Mercurial Diuretics: Their Mechanism of Action and Application
Arch Intern Med, December 1, 1958; 102(6): 1016 - 1023.
[Abstract] [PDF]


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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.