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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 4, 433-443, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF EPINEPHRINE, LEVARTERENOL, AND dl-ISOPROTERENOL ON TRANSMISSION IN THE SUPERIOR CERVICAL GANGLION OF THE CAT

Richard John Matthews Jr. 1

1 Department of Pharmacology, The Jefferson Medical College, Philadelphia, Pennsylvania

Quantitative data are presented on the effect of epinephrine, levarterenol, and dl-isoproterenol on synaptic transmission in the superior cervical ganglion of the decerebrate cat.

Doses of epinephrine, possibly within physiological limits (0.3 to 0.7 microgm./kgm.), depressed synaptic transmission independently of the circulatory effects. On a molar basis epinephrine exerted three times as great an effect as levarterenol in inhibiting ganglionic transmission.

Pentobarbital depressed ganglionic transmission in the decerebrate cat and acted additively with epinephrine and levarterenol in depressing ganglionic transmission.

In doses up to 150 microgm./kgm., neither epinephrine nor levarterenol caused a complete block of ganglionic transmission.

dl-Isoproterenol was shown to augment ganglionic transmission during submaximal stimulation.

Submitted on November 9, 1955






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.