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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 3, 351-355, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

PLASMA CONCENTRATIONS OF EPINEPHRINE AND ARTERENOL FOLLOWING THE ACTIONS OF VARIOUS AGENTS ON THE ADRENALS

E. F. WOODS 1, J. A. RICHARDSON 1, A. K. RICHARDSON 1, and R. F. BOZEMAN Jr. 1

1 Department of Pharmacology, Medical College of South Carolina, Charleston, South Carolina

Intra-aortic injections of eleven widely diversified chemical agents have been investigated with respect to their effects on plasma concentrations of epinephrine and arterenol. Increments in total plasma amines following test agents varied from zero to 60 times control values.

Heart contractile force, arterial blood pressure and heart rate effects produced by these agents were consistently in agreement with the measured changes in plasma amines.

Pentobarbital anesthesia markedly reduced the responsiveness of the adrenal medulla to potassium chloride.

Submitted on October 27, 1955






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