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1 Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
The p-hydroxy derivative of phenobarbital has been found in the urine of dogs and of men after the administration of phenobarbital.
p-Hydroxy phenobarbital has been synthesized and the identity of the synthetic compound with the metabolic product demonstrated.
In dog urine p-hydroxy phenobarbital is almost completely conjugated. The conjugated material consists for the most part of the glucuronide.
In human urine p-hydroxy phenobarbital is only partially conjugated. Little if any of the conjugated material is the glucuronide. It is presumably the sulfate.
p-Hydroxy phenobarbital is not anesthetic in doses as high as 1 gm. per kgm.
The hydroxylation reaction is a mechanism of major importance in the pharmacological inactivation of phenobarbital.
Submitted on October 17, 1955
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