THE EVALUATION OF TWO HALOGENATED SULFOLANES AND PENTYLENETETRAZOL AS ANTAGONISTS TO PENTOBARBITAL

¹ Research Department, Pitman-Moore Company, Division of Allied Laboratories, Inc., Indianapolis, Indiana

The analeptic activity of either 3-bromosulfolane or 3-iodosulfolane in pentobarbital depressed mice was equal to or greater than that for Metrazol.

In these mouse experiments the halo-sulfolanes induced analepsis without untoward effects in a wider dose range than Metrazol.

Intragastric administration to dogs of the three stimulants in fixed ratios with pentobarbital (Metrazol 3:1, 3-bromosulfolane 3:1, and 3-iodosulfolane 0.6:1) revealed that: a. all were capable of prolonging life but could not alter the lethality of pentobarbital, b. only the bromosulfolane significantly increased the time that dogs remained standing and prolonged that for the onset of anesthesia; c. emesis was not induced by the Metrazol combination and its incidence was low for the sulfolane combinations; d. convulsions were produced by the three mixtures, however, only with that of the bromosulfolane was the incidence high (50 per cent).