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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 3, 262-267, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF RESERPINE ON THE HYPOTHALAMIC PRESSOR RESPONSE

FRANK HARRISON 1 and ANDRES GOTH 1

1 Deparments of Anatomy, Pathology, and Pharmacology, The University of Texas Southwestern Medical School, Dallas, Texas

Reserpine in doses of 50-200 microgm. per kgm. produced hypotension, aa marked accentuation of the blood pressure rise following the intravenous injection of levarterenol in anesthetized cats, and a delayed augmentation of the pressor response to hypothalamic stimulation. The hypothalamic pressor augmentation was less than might be expected when compared with the augmentation of the levarterenol response. This difference is interpreted as a reduction in the hypothalamic response as far as the neural centers are concerned which is concealed by an associated decrease in responsiveness of a supraspinal neural mechanism which normally limits the peripheral pressor action of adrenergic agents.

Submitted on August 3, 1955






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.