JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 2, 227-236, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE NEUROTOXICITY AND ANTICHOLINESTERASE PROPERTIES OF SOME SUBSTITUTED PHENYL PHOSPHATES

Charles H. Hine 1, Mary K. Dunlap 1, Evelyn G. Rice 1, Margarita M. Coursey 1, Richard M. Gross 1, and Hamilton H. Anderson 1

1 Department of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco, California

The neurotoxic and anticholinesterase properties of a series of substituted phenyl phosphates have been studied in fowl.

The aromatic phosphates containing one or more orthotolyl groups, and triorthotolyl borate, produced paralysis.

None of the compounds caused inhibition of chicken plasma cholinesterase in vitro. Of the compounds tested, only bis(3,5-dimethylphenyl)chlorophosphite inhibited human erythrocyte cholinesterase in vitro, and only this compound, the corresponding phosphate, and diorthotolyl chlorophosphate inhibited cholinesterase of human plasma in vitro.

None of the compounds tested affected fowl brain cholinesterases severely in vivo, and only triorthotolyl phosphite had a serious effect on cholinesterase in the cord. Fowl plasma cholinesterases were severely inhibited by most of the orthotolyl compounds and by a few not containing this group.

There is no apparent relationship between cholinesterase inhibition and paralysis in fowl.

Submitted on September 16, 1955






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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.