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1 Laboratory of Therapeutical Chemistry, Instituto Superiore di Sanità, Rome, Italy
A study was made of the actions of scopolamine and atropine on cerebral electrical (electroencephalogram) activity and on the neurovegetative and behavioral reactions provoked by stimulation of the hypothalamus in the rabbit.
The two alkaloids markedly influence the electroencephalographic tracing and the electroencephalògraphic activation pattern obtained by stimulation of some subcortical centers with scopolamine exerting its action in doses [unknown] to [unknown] that of atropine.
Both alkaloids proved to be without action on the neurovegetative and behavioral response which follows hypothalamic stimulation.
The relation of these results to the anticholinergic action exerted by the drugs at the level of the central nervous system is discussed.
Submitted on September 3, 1955
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