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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 1, 84-89, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

SEROTONIN AS A MEDIATOR OF RESERPINE ACTION IN BRAIN

Alfred Pletscher 1, Parkhurst A. Shore 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland

The administration of reserpine to rabbits in doses as low as 0.1 mgm. per kgm. releases serotonin in brain. This observation supports the view that serotonin has a role in brain function and that the central action of reserpine is mediated through liberation of serotonin.

Submitted on August 1, 1955




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.