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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 1, 123-129, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE ANTI-EMETIC ACTIVITY OF ALKALOIDS OF RAUWOLFIA SERPENTINA

C. L. Malhotra 1 and R. K. Sidhu 1

1 Department of Pharmacology and Therapeutics, Lady Hardinge Medical College, New Delhi, India

Reserpine and alseroxylon were tested in dogs to determine their anti-emetic action against apomorphine-induced emesis. The Rauwolfia alkaloids were also tested against emesis induced by morphine, ergot (Hydergine), veratrum and oral copper sulphate.

Reserpine and alseroxylon are markedly effective in antagonizing apomorphine-induced emesis. They also protect against vomiting evoked by morphine and ergot, but they are ineffective against emesis induced by veratrum and oral copper sulphate. The pattern of anti-emetic action suggests that the mechanism of action is a selective depression of the medullary emetic chemoreceptor trigger zone.

Submitted on August 17, 1955




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D. X. FREEDMAN and N. J. GIARMAN
Apomorphine Test for Tranquilizing Drugs: Effect of Dibenamine
Science, August 10, 1956; 124(3215): 264 - 265.
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