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Journal of Pharmacology And Experimental Therapeutics, Vol. 116, Issue 1, 114-118, 1956
Copyright © 1956 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ACETYLCHOLINE ON THE CHOLINESTERASES OF CHICK EMBRYO INTESTINE CULTURED IN VITRO

Marion Jones 1, R. M. Featherstone 1, and S. L. Bonting 1

1 Departments of Bacteriology, Pharmacology, and Physiology, College of Medicine, State University of Iowa, Iowa City

Primary explants of chick embryo intestine, cultivated in embryo extract for eight days, lost more than half of their cholinesterase activity on a weight basis, although the cells grew and multiplied well.

Addition of acetylcholine to the medium eliminated this loss of relative enzyme activity.

Cultivation in a synthetic medium, where no increase in protein occurred, resulted in a similar loss of enzyme activity. This loss could again be eliminated by the addition of acetylcholine to the medium.

In all cases the enzyme was predominantly the acetylcholinesterase. It was shown that the criteria for enzyme induction apply to these phenomena. Some considerations adding to the interest of these studies are discussed.

Submitted on August 8, 1955




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Copyright © 1956 by the American Society for Pharmacology and Experimental Therapeutics.